Applications affected by NAT

Some Application Layer protocols (such as FTP and SIP) send explicit network addresses within their application data. FTP in active mode, for example, uses separate connections for control traffic (commands) and for data traffic (file contents). When requesting a file transfer, the host making the request identifies the corresponding data connection by its network layer and transport layer addresses. If the host making the request lies behind a simple NAT firewall, the translation of the IP address and/or TCP port number makes the information received by the server invalid. The Session Initiation Protocol (SIP) controls Voice over IP (VoIP) communications and suffers the same problem . SIP may use multiple ports to set up a connection and transmit voice stream via RTP. IP addresses and port numbers are encoded in the payload data and must be known prior to the traversal of NATs. Without special techniques, such as STUN, NAT behavior is unpredictable and communications may fail.
Application Layer Gateway (ALG) software or hardware may correct these problems. An ALG software module running on a NAT firewall device updates any payload data made invalid by address translation. ALGs obviously need to understand the higher-layer protocol that they need to fix, and so each protocol with this problem requires a separate ALG.
Another possible solution to this problem is to use NAT traversal techniques using protocols such as STUN or ICE or proprietary approaches in a session border controller. NAT traversal is possible in both TCP- and UDP-based applications, but the UDP-based technique is simpler, more widely understood, and more compatible with legacy NATs. In either case, the high level protocol must be designed with NAT traversal in mind, and it does not work reliably across symmetric NATs or other poorly-behaved legacy NATs.
Other possibilities are UPnP (Universal Plug and Play) or Bonjour (NAT-PMP), but these require the cooperation of the NAT device.
Most traditional client-server protocols (FTP being the main exception), however, do not send layer 3 contact information and therefore do not require any special treatment by NATs. In fact, avoiding NAT complications is practically a requirement when designing new higher-layer protocols today.
NATs can also cause problems where IPsec encryption is applied and in cases where multiple devices such as SIP phones are located behind a NAT. Phones which encrypt their signaling with IPsec encapsulate the port information within the IPsec packet meaning that NA(P)T devices cannot access and translate the port. In these cases the NA(P)T devices revert to simple NAT operation. This means that all traffic returning to the NAT will be mapped onto one client causing the service to fail. There are a couple of solutions to this problem, one is to use TLS which operates at level 4 in the OSI Reference Model and therefore does not mask the port number, or to Encapsulate the IPsec within UDP - the latter being the solution chosen by TISPAN to achieve secure NAT traversal.
The DNS protocol vulnerability announced by Dan Kaminsky on 2008 July 8 is indirectly affected by NAT port mapping. To avoid DNS server cache poisoning, it is highly desirable to not translate UDP source port numbers of outgoing DNS requests from any DNS server which is behind a firewall which implements NAT. The recommended work-around for the DNS vulnerability is to make all caching DNS servers use randomized UDP source ports. If the NAT function de-randomizes the UDP source ports, the DNS server will be made vulnerable.